Chen, Chi <br/><br/>
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.  [electronic resource] 

 -  Chemical research in toxicology  Apr 2009 
 - 699-707 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-5010 
<br/><br/><label>Standard No.: </label>10.1021/tx800464q  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Acetaminophen--toxicity<br/>Animals<br/>Carnitine--analogs & derivatives<br/>Chemical and Drug Induced Liver Injury<br/>Chromatography, Liquid<br/>Cytochrome P-450 CYP2E1--deficiency<br/>Fatty Acids--metabolism<br/>Glutathione--metabolism<br/>Liver Diseases--metabolism<br/>Mass Spectrometry<br/>Metabolomics<br/>Mice<br/>Mice, Knockout<br/>PPAR alpha--antagonists & inhibitors<br/>Time Factors