TY - GEN AU - Perloff,E S AU - Mason,A K AU - Dehal,S S AU - Blanchard,A P AU - Morgan,L AU - Ho,T AU - Dandeneau,A AU - Crocker,R M AU - Chandler,C M AU - Boily,N AU - Crespi,C L AU - Stresser,D M TI - Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design SN - 1366-5928 PY - 2009///0624 KW - Chromatography, Liquid KW - Cytochrome P-450 Enzyme Inhibitors KW - Drug Evaluation, Preclinical KW - methods KW - Enzyme Inhibitors KW - pharmacology KW - Humans KW - Inhibitory Concentration 50 KW - Microsomes, Liver KW - drug effects KW - Tandem Mass Spectrometry KW - Time Factors N1 - Publication Type: Journal Article; Validation Study UR - https://doi.org/10.1080/00498250802638155 ER -