Shi, Xianping <br/><br/>
Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation.  [electronic resource] 

 -  Clinical cancer research : an official journal of the American Association for Cancer Research  Mar 2009 
 - 1686-97 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1078-0432 
<br/><br/><label>Standard No.: </label>10.1158/1078-0432.CCR-08-2141  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adolescent<br/>Adult<br/>Aged<br/>Animals<br/>Antineoplastic Agents, Alkylating--therapeutic use<br/>Apoptosis--drug effects<br/>Benzamides<br/>Blotting, Western<br/>Cell Cycle--drug effects<br/>Cell Proliferation--drug effects<br/>Diterpenes--therapeutic use<br/>Drug Resistance, Neoplasm<br/>Epoxy Compounds--therapeutic use<br/>Female<br/>Flow Cytometry<br/>Fusion Proteins, bcr-abl--antagonists & inhibitors<br/>Humans<br/>Imatinib Mesylate<br/>Immunoenzyme Techniques<br/>Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy<br/>Male<br/>Membrane Potential, Mitochondrial--drug effects<br/>Mice<br/>Mice, Inbred BALB C<br/>Mice, Nude<br/>Middle Aged<br/>Mutation--genetics<br/>Myeloid Cell Leukemia Sequence 1 Protein<br/>Phenanthrenes--therapeutic use<br/>Piperazines--therapeutic use<br/>Protein Kinase Inhibitors--therapeutic use<br/>Protein-Tyrosine Kinases--antagonists & inhibitors<br/>Proto-Oncogene Proteins c-akt--genetics<br/>Proto-Oncogene Proteins c-bcl-2--genetics<br/>Pyrimidines--therapeutic use<br/>RNA, Messenger--genetics<br/>Reactive Oxygen Species--metabolism<br/>Reverse Transcriptase Polymerase Chain Reaction<br/>Signal Transduction--drug effects<br/>Transcription, Genetic--drug effects<br/>Tripterygium--chemistry<br/>Tumor Cells, Cultured<br/>Tumor Stem Cell Assay<br/>Xenograft Model Antitumor Assays<br/>Young Adult