TY  - GEN
AU  - Stroh,Mark
AU  - Addy,Carol
AU  - Wu,Yunhui
AU  - Stoch,S Aubrey
AU  - Pourkavoos,Nazaneen
AU  - Groff,Michelle
AU  - Xu,Yang
AU  - Wagner,John
AU  - Gottesdiener,Keith
AU  - Shadle,Craig
AU  - Wang,Hong
AU  - Manser,Kimberly
AU  - Winchell,Gregory A
AU  - Stone,Julie A
TI  - Model-based decision making in early clinical development: minimizing the impact of a blood pressure adverse event
SN  - 1550-7416
PY  - 2009///0723
KW  - Administration, Oral
KW  - Animals
KW  - Biological Availability
KW  - Circadian Rhythm
KW  - Clinical Trials, Phase I as Topic
KW  - statistics & numerical data
KW  - Colon
KW  - Computer Simulation
KW  - Decision Making
KW  - Delayed-Action Preparations
KW  - Dogs
KW  - Dose-Response Relationship, Drug
KW  - Drug Evaluation, Preclinical
KW  - Drugs, Investigational
KW  - administration & dosage
KW  - Gastrointestinal Contents
KW  - chemistry
KW  - Humans
KW  - Hypertension
KW  - chemically induced
KW  - Ileum
KW  - Intestinal Absorption
KW  - Jejunum
KW  - Male
KW  - Models, Biological
KW  - Randomized Controlled Trials as Topic
KW  - Tablets
KW  - Young Adult
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1208/s12248-009-9083-6
ER  -