Secchiero, Paola <br/><br/>
Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism.  [electronic resource] 

 -  Blood  Apr 2009 
 - 4300-8 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1528-0020 
<br/><br/><label>Standard No.: </label>10.1182/blood-2008-11-187708  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adult<br/>Aged<br/>Aged, 80 and over<br/>Amyloid Precursor Protein Secretases--antagonists & inhibitors<br/>Apoptosis<br/>Blotting, Western<br/>Carbamates--pharmacology<br/>Cell Differentiation<br/>Dipeptides--pharmacology<br/>Drug Synergism<br/>Drug Therapy, Combination<br/>Feedback, Physiological<br/>Female<br/>HL-60 Cells<br/>Humans<br/>Imidazoles--pharmacology<br/>Leukemia, Lymphocytic, Chronic, B-Cell--genetics<br/>Male<br/>Middle Aged<br/>Osteoclasts--cytology<br/>Piperazines--pharmacology<br/>RNA, Messenger--metabolism<br/>Receptor, Notch1--genetics<br/>Reverse Transcriptase Polymerase Chain Reaction<br/>Stereoisomerism<br/>Tumor Suppressor Protein p53--antagonists & inhibitors<br/>Up-Regulation