TY  - GEN
AU  - Billottet,Clotilde
AU  - Banerjee,Lalita
AU  - Vanhaesebroeck,Bart
AU  - Khwaja,Asim
TI  - Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation
SN  - 1538-7445
PY  - 2009///0323
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Cell Differentiation
KW  - Cell Growth Processes
KW  - Humans
KW  - Isoenzymes
KW  - Leukemia, Promyelocytic, Acute
KW  - drug therapy
KW  - Myeloid Cell Leukemia Sequence 1 Protein
KW  - Phosphatidylinositol 3-Kinases
KW  - metabolism
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Protein Kinase Inhibitors
KW  - administration & dosage
KW  - Protein Kinases
KW  - Proto-Oncogene Proteins c-akt
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - Signal Transduction
KW  - Sirolimus
KW  - Substrate Specificity
KW  - TOR Serine-Threonine Kinases
KW  - Tretinoin
KW  - Up-Regulation
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/0008-5472.CAN-08-2608
ER  -