Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition. [electronic resource]
- PLoS biology Jan 2009
- e17 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1545-7885
10.1371/journal.pbio.1000017 doi
3-Phosphoinositide-Dependent Protein Kinases Allosteric Regulation--physiology Animals Binding Sites--drug effects Gene Expression Regulation Mice Mutagenesis Phosphorylation Protein Conformation--drug effects Protein Kinase Inhibitors--pharmacology Protein Serine-Threonine Kinases--metabolism Proto-Oncogene Proteins c-akt--antagonists & inhibitors Structure-Activity Relationship