Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells. [electronic resource]
- The Journal of pharmacology and experimental therapeutics Apr 2009
- 112-22 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1521-0103
10.1124/jpet.108.144113 doi
Apoptosis--drug effects Autophagy--drug effects Blotting, Western Capsaicin--analogs & derivatives Cell Line Cell Survival--drug effects Cytoplasm--drug effects Endoplasmic Reticulum--drug effects Enzyme Activation--drug effects Enzyme Inhibitors--pharmacology Fibroblasts--drug effects Flow Cytometry Humans JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors Lung--cytology Microscopy, Electron, Transmission Mitogen-Activated Protein Kinases--metabolism Protein Folding Tetrazolium Salts Thiazoles Transfection Vacuoles--drug effects