Canney, D J <br/><br/>
Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.  [electronic resource] 

 -  Journal of medicinal chemistry  Apr 1991 
 - 1460-7 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm00108a034  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>4-Butyrolactone--analogs & derivatives<br/>Alkylation<br/>Animals<br/>Anticonvulsants--chemical synthesis<br/>Brain--metabolism<br/>Convulsants--chemical synthesis<br/>Female<br/>Ligands<br/>Mice<br/>Mice, Inbred Strains<br/>Molecular Structure<br/>Neurotoxins--chemical synthesis<br/>Picrotoxin--metabolism<br/>Receptors, GABA-A--drug effects<br/>Seizures--physiopathology<br/>Structure-Activity Relationship