Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. [electronic resource]
- Molecular cell Dec 2008
- 838-48 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1097-4164
10.1016/j.molcel.2008.12.004 doi
5' Untranslated Regions--genetics Basic Helix-Loop-Helix Transcription Factors--biosynthesis Cell Hypoxia--drug effects Cell Proliferation--drug effects Culture Media, Conditioned Dose-Response Relationship, Drug Endothelial Cells--cytology Gene Expression Profiling Gene Expression Regulation--drug effects Humans Iron--metabolism Iron Chelating Agents--pharmacology Iron-Regulatory Proteins--metabolism Oxygen--pharmacology Protein Binding--drug effects Protein Biosynthesis--drug effects Protein Kinases--metabolism Protein Stability--drug effects RNA Stability--drug effects RNA, Messenger--genetics Receptors, Transferrin--genetics Response Elements--genetics Small Molecule Libraries--analysis TOR Serine-Threonine Kinases