A novel reciprocal and biphasic relationship between membrane cholesterol and beta-secretase activity in SH-SY5Y cells and in human platelets. [electronic resource]
- Journal of neurochemistry Jan 2009
- 341-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1471-4159
10.1111/j.1471-4159.2008.05753.x doi
Aged Aged, 80 and over Alzheimer Disease--blood Amyloid Precursor Protein Secretases--antagonists & inhibitors Aspartic Acid Endopeptidases--metabolism Blood Platelets--cytology Case-Control Studies Cell Line, Tumor Cell Membrane--drug effects Cholesterol--metabolism Cognition Disorders--blood Culture Media, Serum-Free--pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors Enzyme-Linked Immunosorbent Assay--methods Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology Linear Models Male Neuroblastoma--pathology Statistics, Nonparametric Subcellular Fractions Time Factors beta-Cyclodextrins--pharmacology