TY  - GEN
AU  - Kingsbury,W D
AU  - Boehm,J C
AU  - Jakas,D R
AU  - Holden,K G
AU  - Hecht,S M
AU  - Gallagher,G
AU  - Caranfa,M J
AU  - McCabe,F L
AU  - Faucette,L F
AU  - Johnson,R K
TI  - Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity
SN  - 0022-2623
PY  - 1991///0312
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Camptothecin
KW  - analogs & derivatives
KW  - Cattle
KW  - Cell Line
KW  - Colonic Neoplasms
KW  - drug therapy
KW  - DNA, Superhelical
KW  - drug effects
KW  - Drug Evaluation, Preclinical
KW  - Drug Screening Assays, Antitumor
KW  - Humans
KW  - Indicators and Reagents
KW  - Leukemia L1210
KW  - Lung Neoplasms
KW  - Melanoma, Experimental
KW  - Mice
KW  - Molecular Structure
KW  - Plasmids
KW  - Structure-Activity Relationship
KW  - Thymus Gland
KW  - enzymology
KW  - Topoisomerase I Inhibitors
KW  - Transplantation, Heterologous
N1  - Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1021/jm00105a017
ER  -