TY  - GEN
AU  - Costello,G F
AU  - James,R
AU  - Shaw,J S
AU  - Slater,A M
AU  - Stutchbury,N C
TI  - 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists
SN  - 0022-2623
PY  - 1991///0312
KW  - Acetamides
KW  - chemical synthesis
KW  - Analgesia
KW  - Analgesics
KW  - Animals
KW  - Female
KW  - Guinea Pigs
KW  - In Vitro Techniques
KW  - Indicators and Reagents
KW  - Male
KW  - Mice
KW  - Mice, Inbred Strains
KW  - Molecular Conformation
KW  - Molecular Structure
KW  - Muscle, Smooth
KW  - drug effects
KW  - Naloxone
KW  - metabolism
KW  - Pyrrolidines
KW  - Receptors, Opioid
KW  - Receptors, Opioid, mu
KW  - Structure-Activity Relationship
KW  - Vas Deferens
KW  - X-Ray Diffraction
N1  - Publication Type: Comparative Study; Journal Article
UR  - https://doi.org/10.1021/jm00105a027
ER  -