Costello, G F <br/><br/>
2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists.  [electronic resource] 

 -  Journal of medicinal chemistry  Jan 1991 
 - 181-9 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm00105a027  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Acetamides--chemical synthesis<br/>Analgesia<br/>Analgesics--chemical synthesis<br/>Animals<br/>Female<br/>Guinea Pigs<br/>In Vitro Techniques<br/>Indicators and Reagents<br/>Male<br/>Mice<br/>Mice, Inbred Strains<br/>Molecular Conformation<br/>Molecular Structure<br/>Muscle, Smooth--drug effects<br/>Naloxone--metabolism<br/>Pyrrolidines--chemical synthesis<br/>Receptors, Opioid--drug effects<br/>Receptors, Opioid, mu<br/>Structure-Activity Relationship<br/>Vas Deferens--drug effects<br/>X-Ray Diffraction