Kneteman, Norman M

HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus. [electronic resource] - Hepatology (Baltimore, Md.) Mar 2009 - 745-52 p. digital

Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

1527-3350

10.1002/hep.22717 doi


Animals
Antiviral Agents--pharmacology
Benzofurans--pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Double-Blind Method
Drug Therapy, Combination
Enzyme Inhibitors--pharmacology
Hepacivirus--drug effects
Hepatitis C--drug therapy
Hepatocytes--transplantation
Humans
Interferon alpha-2
Interferon-alpha--therapeutic use
Liver--drug effects
Mice
Mice, SCID
Polyethylene Glycols
Recombinant Proteins
Replicon--drug effects
Ribavirin--therapeutic use
Sulfonamides--pharmacology
Viral Nonstructural Proteins--antagonists & inhibitors