Guruvayoorappan, Chandrasekharan <br/><br/>
Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages.  [electronic resource] 

 -  Journal of experimental therapeutics & oncology  2008 
 - 207-18 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1359-4117 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Apoptosis--drug effects<br/>Biflavonoids--pharmacology<br/>Caspase 3--genetics<br/>Cells, Cultured<br/>Cytokines--metabolism<br/>Gene Expression Regulation, Neoplastic--drug effects<br/>Granulocyte-Macrophage Colony-Stimulating Factor--metabolism<br/>Interleukin-1beta--metabolism<br/>Interleukin-6--metabolism<br/>Macrophages--drug effects<br/>Melanoma, Experimental--genetics<br/>Mice<br/>Mice, Inbred C57BL<br/>Nitrates--metabolism<br/>Nitric Oxide--metabolism<br/>Nitric Oxide Synthase Type II--genetics<br/>Proto-Oncogene Proteins c-bcl-2--genetics<br/>RNA, Messenger--genetics<br/>Reverse Transcriptase Polymerase Chain Reaction<br/>Tumor Necrosis Factor-alpha--metabolism<br/>Tumor Suppressor Protein p53--genetics