Mayer, Scott C <br/><br/>
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.  [electronic resource] 

 -  Journal of medicinal chemistry  Dec 2008 
 - 7348-51 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm801252w  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alzheimer Disease--drug therapy<br/>Amyloid Precursor Protein Secretases--antagonists & inhibitors<br/>Amyloid beta-Peptides--metabolism<br/>Animals<br/>Crystallography, X-Ray<br/>Disease Models, Animal<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>Enzyme Inhibitors--chemical synthesis<br/>Mice<br/>Mice, Transgenic<br/>Models, Molecular<br/>Molecular Conformation<br/>Receptor, Notch1--metabolism<br/>Stereoisomerism<br/>Structure-Activity Relationship<br/>Sulfonamides--chemical synthesis<br/>Thiophenes--chemical synthesis