Zhang, Bin <br/><br/>
Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases.  [electronic resource] 

 -  Journal of medicinal chemistry  Dec 2008 
 - 7352-5 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm801146d  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--chemical synthesis<br/>Apoptosis--drug effects<br/>Binding Sites<br/>Biomimetic Materials--chemical synthesis<br/>Caspase Inhibitors<br/>Caspases--metabolism<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Crystallography, X-Ray<br/>Cyclization<br/>Dose-Response Relationship, Drug<br/>Drug Design<br/>Drug Evaluation, Preclinical<br/>Drug Screening Assays, Antitumor<br/>Enzyme Inhibitors--chemical synthesis<br/>Humans<br/>Inhibitor of Apoptosis Proteins--antagonists & inhibitors<br/>Mitochondria--enzymology<br/>Models, Molecular<br/>Molecular Conformation<br/>Molecular Weight<br/>Stereoisomerism<br/>Structure-Activity Relationship