TY - GEN AU - Fels,Diane R AU - Ye,Jiangbin AU - Segan,Andrew T AU - Kridel,Steven J AU - Spiotto,Michael AU - Olson,Michael AU - Koong,Albert C AU - Koumenis,Constantinos TI - Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways SN - 1538-7445 PY - 2008///1210 KW - Activating Transcription Factor 4 KW - genetics KW - Antineoplastic Agents KW - pharmacology KW - Apoptosis KW - Autophagy KW - Boronic Acids KW - Bortezomib KW - Cell Hypoxia KW - Cell Line, Tumor KW - DNA-Binding Proteins KW - Endoplasmic Reticulum KW - drug effects KW - Humans KW - Microtubule-Associated Proteins KW - metabolism KW - Necrosis KW - Protease Inhibitors KW - Protein Folding KW - Pyrazines KW - Regulatory Factor X Transcription Factors KW - Signal Transduction KW - Stress, Physiological KW - Thapsigargin KW - Transcription Factors N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1158/0008-5472.CAN-08-2873 ER -