TY - GEN AU - Zeng,Zhihong AU - Shi,Yue Xi AU - Samudio,Ismael J AU - Wang,Rui-Yu AU - Ling,Xiaoyang AU - Frolova,Olga AU - Levis,Mark AU - Rubin,Joshua B AU - Negrin,Robert R AU - Estey,Elihu H AU - Konoplev,Sergej AU - Andreeff,Michael AU - Konopleva,Marina TI - Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML SN - 1528-0020 PY - 2009///0716 KW - Animals KW - Antineoplastic Agents KW - pharmacology KW - Apoptosis KW - drug effects KW - Blotting, Western KW - Cell Movement KW - Cell Proliferation KW - Cells, Cultured KW - Chemokine CXCL12 KW - genetics KW - Chemotaxis KW - Drug Resistance, Neoplasm KW - Flow Cytometry KW - Humans KW - Immunoenzyme Techniques KW - Leukemia, Experimental KW - drug therapy KW - Leukemia, Myeloid, Acute KW - Mice KW - Mice, Inbred BALB C KW - Mutation KW - Protein Kinase Inhibitors KW - Pyridines KW - Receptors, CXCR4 KW - antagonists & inhibitors KW - Stromal Cells KW - fms-Like Tyrosine Kinase 3 N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1182/blood-2008-05-158311 ER -