TY  - GEN
AU  - Dyck,Brian
AU  - Tamiya,Junko
AU  - Jovic,Florence
AU  - Pick,Rebecca R
AU  - Bradbury,Margaret J
AU  - O'Brien,Julie
AU  - Wen,Jenny
AU  - Johns,Michael
AU  - Madan,Ajay
AU  - Fleck,Beth A
AU  - Foster,Alan C
AU  - Li,Binfeng
AU  - Zhang,Mingzhu
AU  - Tran,Joe A
AU  - Vickers,Troy
AU  - Grey,Jonathan
AU  - Saunders,John
AU  - Chen,Chen
TI  - Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain
SN  - 1520-4804
PY  - 2009///0403
KW  - Administration, Oral
KW  - Animals
KW  - Biological Availability
KW  - Caco-2 Cells
KW  - Crystallography, X-Ray
KW  - Cyclopropanes
KW  - chemistry
KW  - Disease Models, Animal
KW  - Dose-Response Relationship, Drug
KW  - Drug Design
KW  - Humans
KW  - Male
KW  - Microsomes, Liver
KW  - Milnacipran
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Molecular Weight
KW  - Neuralgia
KW  - drug therapy
KW  - Norepinephrine Plasma Membrane Transport Proteins
KW  - antagonists & inhibitors
KW  - Pain Measurement
KW  - drug effects
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Serotonin Plasma Membrane Transport Proteins
KW  - metabolism
KW  - Selective Serotonin Reuptake Inhibitors
KW  - Spinal Nerves
KW  - pathology
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm8009537
ER  -