Dyck, Brian <br/><br/>
Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain.  [electronic resource] 

 -  Journal of medicinal chemistry  Nov 2008 
 - 7265-72 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm8009537  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Biological Availability<br/>Caco-2 Cells<br/>Crystallography, X-Ray<br/>Cyclopropanes--chemistry<br/>Disease Models, Animal<br/>Dose-Response Relationship, Drug<br/>Drug Design<br/>Humans<br/>Male<br/>Microsomes, Liver--chemistry<br/>Milnacipran<br/>Models, Molecular<br/>Molecular Structure<br/>Molecular Weight<br/>Neuralgia--drug therapy<br/>Norepinephrine Plasma Membrane Transport Proteins--antagonists & inhibitors<br/>Pain Measurement--drug effects<br/>Rats<br/>Rats, Sprague-Dawley<br/>Serotonin Plasma Membrane Transport Proteins--metabolism<br/>Selective Serotonin Reuptake Inhibitors--chemistry<br/>Spinal Nerves--pathology<br/>Stereoisomerism<br/>Structure-Activity Relationship