Al Rahim, Md

A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons. [electronic resource] - European journal of pharmacology Dec 2008 - 10-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-0712

10.1016/j.ejphar.2008.09.046 doi


Alzheimer Disease--drug therapy
Amyloid beta-Peptides--antagonists & inhibitors
Animals
Cells, Cultured
Cerebral Cortex--cytology
Cyclic AMP--metabolism
Cyclic AMP Response Element-Binding Protein--metabolism
Cyclic AMP-Dependent Protein Kinases--drug effects
Dose-Response Relationship, Drug
Extracellular Signal-Regulated MAP Kinases--drug effects
Mitogen-Activated Protein Kinases--drug effects
Neurons--drug effects
Phosphorylation--drug effects
Propiophenones--administration & dosage
Rats
Rats, Sprague-Dawley
Signal Transduction--drug effects
Time Factors