Smith, J R <br/><br/>
Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors.  [electronic resource] 

 -  Oncogene  Jan 2009 
 - 157-69 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1476-5594 
<br/><br/><label>Standard No.: </label>10.1038/onc.2008.380  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adenocarcinoma--metabolism<br/>Apoptosis--drug effects<br/>Benzoquinones--pharmacology<br/>Breast Neoplasms--metabolism<br/>Cell Cycle Proteins--antagonists & inhibitors<br/>Cell Division--drug effects<br/>Cell Line, Tumor--drug effects<br/>Chaperonins--antagonists & inhibitors<br/>Colonic Neoplasms--metabolism<br/>Female<br/>G1 Phase--drug effects<br/>Gene Expression Regulation, Neoplastic--drug effects<br/>Gene Targeting<br/>HSP90 Heat-Shock Proteins--antagonists & inhibitors<br/>Humans<br/>Lactams, Macrocyclic--pharmacology<br/>Male<br/>Neoplasm Proteins--antagonists & inhibitors<br/>Phosphorylation--drug effects<br/>Prostatic Neoplasms--metabolism<br/>Proteasome Endopeptidase Complex--metabolism<br/>Protein Kinases--metabolism<br/>Protein Processing, Post-Translational--drug effects<br/>Pyrazoles--pharmacology<br/>RNA Interference<br/>RNA, Small Interfering--pharmacology<br/>Signal Transduction--drug effects