TY - GEN AU - Krakoff,Jonathan AU - Ma,Lijun AU - Kobes,Sayuko AU - Knowler,William C AU - Hanson,Robert L AU - Bogardus,Clifton AU - Baier,Leslie J TI - Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant SN - 1939-327X PY - 2008///1231 KW - Amino Acid Substitution KW - Arginine KW - Arizona KW - epidemiology KW - Basal Metabolism KW - genetics KW - Body Mass Index KW - DNA Transposable Elements KW - Frameshift Mutation KW - Genetic Carrier Screening KW - Genetic Variation KW - Glutamine KW - Humans KW - Hyperinsulinism KW - Hyperphagia KW - Indians, North American KW - Mutation, Missense KW - Obesity KW - Polymorphism, Single Nucleotide KW - Prevalence KW - Receptor, Melanocortin, Type 4 N1 - Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.2337/db08-0577 ER -