Novel double coated nanocapsules for intestinal delivery and enhanced oral bioavailability of tacrolimus, a P-gp substrate drug. [electronic resource]
- Journal of controlled release : official journal of the Controlled Release Society Jan 2009
- 77-84 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1873-4995
10.1016/j.jconrel.2008.08.021 doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism Administration, Oral Analysis of Variance Animals Area Under Curve Biological Availability Drug Delivery Systems--methods Enterocytes--metabolism Hypromellose Derivatives Immunosuppressive Agents--chemistry Intestinal Absorption Intestinal Mucosa--metabolism Intestines--pathology Methylcellulose--analogs & derivatives Microscopy, Electron, Scanning Microspheres Nanocapsules--chemistry Particle Size Plant Oils--chemistry Polymethacrylic Acids--chemistry Rats Rats, Sprague-Dawley Surface Properties Swine Tacrolimus--chemistry