Dragovich, Peter S <br/><br/>
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Oct 2008 
 - 5635-9 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2008.08.094  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antiviral Agents--chemical synthesis<br/>Caco-2 Cells<br/>Chemistry, Pharmaceutical--methods<br/>Crystallography, X-Ray--methods<br/>Cyclic S-Oxides--chemical synthesis<br/>DNA-Directed RNA Polymerases--chemistry<br/>Drug Design<br/>Genotype<br/>Humans<br/>Inhibitory Concentration 50<br/>Microsomes--metabolism<br/>Models, Chemical<br/>Molecular Conformation<br/>Pyridazines--chemical synthesis<br/>Structure-Activity Relationship<br/>Thiadiazines--chemical synthesis<br/>Viral Nonstructural Proteins--antagonists & inhibitors