TY - GEN AU - Hashizume,M AU - Hayakawa,N AU - Mihara,M TI - IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17 SN - 1462-0332 PY - 2008///1216 KW - Antibodies, Monoclonal KW - pharmacology KW - Antibodies, Monoclonal, Humanized KW - Arthritis, Rheumatoid KW - metabolism KW - Blotting, Western KW - methods KW - Cell Proliferation KW - drug effects KW - Cells, Cultured KW - Fibroblasts KW - Flavonoids KW - Humans KW - Immunohistochemistry KW - Interleukin-17 KW - Interleukin-1beta KW - Interleukin-6 KW - Mitogen-Activated Protein Kinase Kinases KW - antagonists & inhibitors KW - Phosphorylation KW - RANK Ligand KW - analysis KW - RNA, Messenger KW - Receptor Activator of Nuclear Factor-kappa B KW - Receptors, Interleukin-6 KW - Recombinant Proteins KW - Reverse Transcriptase Polymerase Chain Reaction KW - STAT3 Transcription Factor KW - Sesquiterpenes KW - Signal Transduction KW - physiology KW - Stimulation, Chemical KW - Synovial Membrane KW - Tumor Necrosis Factor-alpha N1 - Publication Type: Journal Article UR - https://doi.org/10.1093/rheumatology/ken363 ER -