TY  - GEN
AU  - Cole,Derek C
AU  - Asselin,Magda
AU  - Brennan,Agnes
AU  - Czerwinski,Robert
AU  - Ellingboe,John W
AU  - Fitz,Lori
AU  - Greco,Rita
AU  - Huang,Xinyi
AU  - Joseph-McCarthy,Diane
AU  - Kelly,Michael F
AU  - Kirisits,Matthew
AU  - Lee,Julie
AU  - Li,Yuanhong
AU  - Morgan,Paul
AU  - Stock,Joseph R
AU  - Tsao,Désirée H H
AU  - Wissner,Allan
AU  - Yang,Xiaoke
AU  - Chaudhary,Divya
TI  - Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors
SN  - 1520-4804
PY  - 2008///1030
KW  - Animals
KW  - Crystallography, X-Ray
KW  - Dose-Response Relationship, Drug
KW  - Drug Evaluation, Preclinical
KW  - Female
KW  - Indoles
KW  - chemical synthesis
KW  - Interleukin-2
KW  - antagonists & inhibitors
KW  - Isoenzymes
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Nitriles
KW  - Protein Kinase C
KW  - Protein Kinase C-theta
KW  - Protein Kinase Inhibitors
KW  - Pyridines
KW  - Spleen
KW  - cytology
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - T-Lymphocytes
KW  - drug effects
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm800214a
ER  -