Mandimika, Tafadzwa

PI3K/AKT, JNK, and ERK pathways are not crucial for the induction of cholesterol biosynthesis gene transcription in intestinal epithelial cells following treatment with the potato glycoalkaloid alpha-chaconine. [electronic resource] - Journal of agricultural and food chemistry Sep 2008 - 8745-52 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-5118

10.1021/jf800911m doi


Caco-2 Cells
Cholesterol--biosynthesis
Epithelial Cells--metabolism
Extracellular Signal-Regulated MAP Kinases--metabolism
Gene Expression--drug effects
Humans
Intestinal Mucosa--metabolism
JNK Mitogen-Activated Protein Kinases--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Phosphorylation
Proto-Oncogene Proteins c-akt--metabolism
Solanine--analogs & derivatives
Solanum tuberosum--chemistry
Sterol Regulatory Element Binding Protein 2--genetics