Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. [electronic resource]
- Genes & development Aug 2008
- 2172-7 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0890-9369
10.1101/gad.1699608 doi
Animals Blotting, Western Cell Line, Tumor Cell Transformation, Neoplastic--pathology Chromosome Aberrations Humans Male Mechanistic Target of Rapamycin Complex 1 Mice Mice, Transgenic Monomeric GTP-Binding Proteins--physiology Multiprotein Complexes Neuropeptides--physiology PTEN Phosphohydrolase--physiology Prostatic Intraepithelial Neoplasia--etiology Prostatic Neoplasms--etiology Proteins Proto-Oncogene Mas RNA, Messenger--genetics Ras Homolog Enriched in Brain Protein Reverse Transcriptase Polymerase Chain Reaction Signal Transduction TOR Serine-Threonine Kinases Transcription Factors--physiology