Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins. [electronic resource]
- Journal of medicinal chemistry Sep 2008
- 5371-86 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
1520-4804
10.1021/jm800380b doi
Cell Membrane Permeability Diglycerides--chemistry Guanine Nucleotide Exchange Factors--metabolism Heterocyclic Compounds Humans Hydrophobic and Hydrophilic Interactions Lactones--chemistry Molecular Conformation Protein Binding Protein Kinase C-alpha--metabolism ras Guanine Nucleotide Exchange Factors