El Kazzouli, Saïd

Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins. [electronic resource] - Journal of medicinal chemistry Sep 2008 - 5371-86 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Intramural

1520-4804

10.1021/jm800380b doi


Cell Membrane Permeability
Diglycerides--chemistry
Guanine Nucleotide Exchange Factors--metabolism
Heterocyclic Compounds
Humans
Hydrophobic and Hydrophilic Interactions
Lactones--chemistry
Molecular Conformation
Protein Binding
Protein Kinase C-alpha--metabolism
ras Guanine Nucleotide Exchange Factors