TY  - GEN
AU  - Krige,David
AU  - Needham,Lindsey A
AU  - Bawden,Lindsay J
AU  - Flores,Nicolas
AU  - Farmer,Hannah
AU  - Miles,Lauren E C
AU  - Stone,Erica
AU  - Callaghan,Juliana
AU  - Chandler,Stephen
AU  - Clark,Vanessa L
AU  - Kirwin-Jones,Patricia
AU  - Legris,Valérie
AU  - Owen,Jo
AU  - Patel,Thakor
AU  - Wood,Steve
AU  - Box,Gary
AU  - Laber,David
AU  - Odedra,Rajesh
AU  - Wright,Annette
AU  - Wood,L Michael
AU  - Eccles,Suzanne A
AU  - Bone,Elisabeth A
AU  - Ayscough,Andrew
AU  - Drummond,Alan H
TI  - CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells
SN  - 1538-7445
PY  - 2008///1002
KW  - Amino Acids
KW  - metabolism
KW  - Aminopeptidases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Biomarkers, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Electrophoresis, Polyacrylamide Gel
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Eukaryotic Initiation Factor-2
KW  - Gene Expression Profiling
KW  - Gene Expression Regulation, Leukemic
KW  - Glycine
KW  - analogs & derivatives
KW  - HL-60 Cells
KW  - Humans
KW  - Hydroxamic Acids
KW  - Immunoblotting
KW  - Leucine
KW  - Mice
KW  - Oligonucleotide Array Sequence Analysis
KW  - Peptide Fragments
KW  - Phenylalanine
KW  - Phosphorylation
KW  - Protein Kinases
KW  - Protein Synthesis Inhibitors
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - RNA, Messenger
KW  - genetics
KW  - Rats
KW  - Reverse Transcriptase Polymerase Chain Reaction
KW  - TOR Serine-Threonine Kinases
KW  - Thiophenes
KW  - Tumor Cells, Cultured
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1158/0008-5472.CAN-07-6627
ER  -