Wiscount, Catherine M <br/><br/>
10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Aug 2008 
 - 4581-3 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2008.07.037  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Antiviral Agents--pharmacology<br/>Biological Availability<br/>Chemistry, Pharmaceutical--methods<br/>Drug Design<br/>HIV Integrase--chemical synthesis<br/>Humans<br/>Inhibitory Concentration 50<br/>Integrases--genetics<br/>Models, Chemical<br/>Mutation<br/>Rats<br/>Structure-Activity Relationship<br/>Virus Replication