TY - GEN AU - Lanke,Elsa AU - Kristoffersson,Ann-Charlotte AU - Isaksson,Christina AU - Holmberg,Lars AU - Lethagen,Stefan TI - N1421K mutation in the glycoprotein Ib binding domain impairs ristocetin- and botrocetin-mediated binding of von Willebrand factor to platelets SN - 1600-0609 PY - 2008///1118 KW - Amino Acid Substitution KW - Animals KW - Anti-Bacterial Agents KW - pharmacology KW - Binding Sites KW - genetics KW - Blood Platelets KW - metabolism KW - COS Cells KW - Chlorocebus aethiops KW - Collagen KW - Crotalid Venoms KW - Factor VIII KW - Family KW - Female KW - Heterozygote KW - Humans KW - Male KW - Mutation, Missense KW - Pedigree KW - Platelet Adhesiveness KW - drug effects KW - Platelet Aggregation KW - Platelet Glycoprotein GPIb-IX Complex KW - Protein Binding KW - Protein Structure, Tertiary KW - Ristocetin KW - von Willebrand Diseases KW - von Willebrand Factor N1 - Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1111/j.1600-0609.2008.01123.x ER -