TY  - GEN
AU  - Rawson,Thomas E
AU  - Rüth,Matthias
AU  - Blackwood,Elizabeth
AU  - Burdick,Dan
AU  - Corson,Laura
AU  - Dotson,Jenna
AU  - Drummond,Jason
AU  - Fields,Carter
AU  - Georges,Guy J
AU  - Goller,Bernhard
AU  - Halladay,Jason
AU  - Hunsaker,Thomas
AU  - Kleinheinz,Tracy
AU  - Krell,Hans-Willi
AU  - Li,Jun
AU  - Liang,Jun
AU  - Limberg,Anja
AU  - McNutt,Angela
AU  - Moffat,John
AU  - Phillips,Gail
AU  - Ran,Yingqing
AU  - Safina,Brian
AU  - Ultsch,Mark
AU  - Walker,Leslie
AU  - Wiesmann,Christian
AU  - Zhang,Birong
AU  - Zhou,Aihe
AU  - Zhu,Bing-Yan
AU  - Rüger,Petra
AU  - Cochran,Andrea G
TI  - A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability
SN  - 1520-4804
PY  - 2008///0908
KW  - Administration, Oral
KW  - Animals
KW  - Aurora Kinase A
KW  - Aurora Kinase B
KW  - Aurora Kinases
KW  - Benzimidazoles
KW  - chemical synthesis
KW  - Biological Availability
KW  - Cell Line, Tumor
KW  - Crystallography, X-Ray
KW  - Dogs
KW  - Heterocyclic Compounds, 4 or More Rings
KW  - administration & dosage
KW  - Humans
KW  - Lactams
KW  - chemistry
KW  - Mice
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Protein Kinase Inhibitors
KW  - Protein Serine-Threonine Kinases
KW  - antagonists & inhibitors
KW  - Rats
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1021/jm800052b
ER  -