Rawson, Thomas E <br/><br/>
A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability.  [electronic resource] 

 -  Journal of medicinal chemistry  Aug 2008 
 - 4465-75 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm800052b  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Aurora Kinase A<br/>Aurora Kinase B<br/>Aurora Kinases<br/>Benzimidazoles--chemical synthesis<br/>Biological Availability<br/>Cell Line, Tumor<br/>Crystallography, X-Ray<br/>Dogs<br/>Heterocyclic Compounds, 4 or More Rings--administration & dosage<br/>Humans<br/>Lactams--chemistry<br/>Mice<br/>Models, Molecular<br/>Molecular Structure<br/>Protein Kinase Inhibitors--administration & dosage<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Rats