Wang, Shizhen Emily <br/><br/>
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab.  [electronic resource] 

 -  Molecular and cellular biology  Sep 2008 
 - 5605-20 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1098-5549 
<br/><br/><label>Standard No.: </label>10.1128/MCB.00787-08  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>ADAM Proteins--genetics<br/>ADAM17 Protein<br/>Antibodies, Monoclonal--therapeutic use<br/>Antibodies, Monoclonal, Humanized<br/>Antineoplastic Agents--therapeutic use<br/>Breast Neoplasms--drug therapy<br/>Cells, Cultured<br/>Enzyme Activation<br/>Female<br/>Gene Expression Profiling<br/>Humans<br/>Oligonucleotide Array Sequence Analysis<br/>Phosphatidylinositol 3-Kinases--genetics<br/>Proto-Oncogene Proteins c-akt--genetics<br/>RNA Interference<br/>Receptor, ErbB-2--genetics<br/>Signal Transduction--physiology<br/>Transforming Growth Factor alpha--metabolism<br/>Transforming Growth Factor beta--metabolism<br/>Trastuzumab<br/>Treatment Outcome