TY  - GEN
AU  - Whelan,Harry T
AU  - Cook,John D
AU  - Amlie-Lefond,Catherine M
AU  - Hovinga,Collin A
AU  - Chan,Anthony K
AU  - Ichord,Rebecca N
AU  - Deveber,Gabrielle A
AU  - Thall,Peter F
TI  - Practical model-based dose finding in early-phase clinical trials: optimizing tissue plasminogen activator dose for treatment of ischemic stroke in children
SN  - 1524-4628
PY  - 2008///0925
KW  - Adolescent
KW  - Age Factors
KW  - Bayes Theorem
KW  - Brain Ischemia
KW  - drug therapy
KW  - Child
KW  - Child, Preschool
KW  - Clinical Protocols
KW  - Clinical Trials as Topic
KW  - methods
KW  - Cohort Studies
KW  - Computer Simulation
KW  - Dose-Response Relationship, Drug
KW  - Drug-Related Side Effects and Adverse Reactions
KW  - Fibrinolytic Agents
KW  - administration & dosage
KW  - Humans
KW  - Infant
KW  - Models, Statistical
KW  - Research Design
KW  - Stroke
KW  - Tissue Plasminogen Activator
KW  - Treatment Outcome
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1161/STROKEAHA.107.510164
ER  -