Whelan, Harry T <br/><br/>
Practical model-based dose finding in early-phase clinical trials: optimizing tissue plasminogen activator dose for treatment of ischemic stroke in children.  [electronic resource] 

 -  Stroke  Sep 2008 
 - 2627-36 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1524-4628 
<br/><br/><label>Standard No.: </label>10.1161/STROKEAHA.107.510164  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adolescent<br/>Age Factors<br/>Bayes Theorem<br/>Brain Ischemia--drug therapy<br/>Child<br/>Child, Preschool<br/>Clinical Protocols<br/>Clinical Trials as Topic--methods<br/>Cohort Studies<br/>Computer Simulation<br/>Dose-Response Relationship, Drug<br/>Drug-Related Side Effects and Adverse Reactions<br/>Fibrinolytic Agents--administration & dosage<br/>Humans<br/>Infant<br/>Models, Statistical<br/>Research Design<br/>Stroke--drug therapy<br/>Tissue Plasminogen Activator--administration & dosage<br/>Treatment Outcome