Formation of tissue factor-factor VIIa-factor Xa complex induces activation of the mTOR pathway which regulates migration of human breast cancer cells. [electronic resource]
- Thrombosis and haemostasis Jul 2008
- 127-33 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
0340-6245
10.1160/TH07-12-0722 doi
Breast Neoplasms--enzymology Cell Line, Tumor Cell Movement--drug effects Chromones--pharmacology Factor VIIa--metabolism Factor Xa--metabolism Female Humans Morpholines--pharmacology Neoplasm Invasiveness Peptides--pharmacology Phosphorylation Protein Kinase Inhibitors--pharmacology Protein Kinases--drug effects Proto-Oncogene Proteins c-akt--antagonists & inhibitors Receptor, PAR-1--metabolism Receptor, PAR-2--metabolism Recombinant Proteins--metabolism Ribosomal Protein S6 Kinases, 70-kDa--metabolism Sirolimus--pharmacology TOR Serine-Threonine Kinases Thromboplastin--metabolism