TY  - GEN
AU  - Hoffmann,Jens
AU  - Vitale,Ilio
AU  - Buchmann,Bernd
AU  - Galluzzi,Lorenzo
AU  - Schwede,Wolfgang
AU  - Senovilla,Laura
AU  - Skuballa,Werner
AU  - Vivet,Sonia
AU  - Lichtner,Rosemarie B
AU  - Vicencio,José M
AU  - Panaretakis,Theocharis
AU  - Siemeister,Gerhard
AU  - Lage,Hermann
AU  - Nanty,Lisa
AU  - Hammer,Stefanie
AU  - Mittelstaedt,Kevin
AU  - Winsel,Sebastian
AU  - Eschenbrenner,Julia
AU  - Castedo,Maria
AU  - Demarche,Carine
AU  - Klar,Ulrich
AU  - Kroemer,Guido
TI  - Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone
SN  - 1538-7445
PY  - 2008///0805
KW  - Animals
KW  - Antineoplastic Agents
KW  - pharmacokinetics
KW  - Apoptosis
KW  - drug effects
KW  - Benzothiazoles
KW  - Epothilones
KW  - HCT116 Cells
KW  - HeLa Cells
KW  - Humans
KW  - Mice
KW  - Mitochondria
KW  - Neoplasms
KW  - metabolism
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - physiology
KW  - Tissue Distribution
KW  - Tubulin
KW  - Tumor Cells, Cultured
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/0008-5472.CAN-08-0237
ER  -