TY  - GEN
AU  - Bertram,Lisa S
AU  - Black,Daniel
AU  - Briner,Paul H
AU  - Chatfield,Rosemary
AU  - Cooke,Andrew
AU  - Fyfe,Matthew C T
AU  - Murray,P John
AU  - Naud,Frédéric
AU  - Nawano,Masao
AU  - Procter,Martin J
AU  - Rakipovski,Günaj
AU  - Rasamison,Chrystelle M
AU  - Reynet,Christine
AU  - Schofield,Karen L
AU  - Shah,Vilas K
AU  - Spindler,Felix
AU  - Taylor,Amanda
AU  - Turton,Roy
AU  - Williams,Geoffrey M
AU  - Wong-Kai-In,Philippe
AU  - Yasuda,Kosuke
TI  - SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1
SN  - 1520-4804
PY  - 2008///0829
KW  - Animals
KW  - Enzyme Activation
KW  - Female
KW  - Glucokinase
KW  - metabolism
KW  - Hypoglycemic Agents
KW  - adverse effects
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Microsomes, Liver
KW  - enzymology
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Spectrometry, Mass, Electrospray Ionization
KW  - Structure-Activity Relationship
KW  - Sulfones
KW  - Thiazoles
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm8003202
ER  -