Youdim, Kuresh A <br/><br/>
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.  [electronic resource] 

 -  Journal of pharmaceutical and biomedical analysis  Sep 2008 
 - 92-9 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0731-7085 
<br/><br/><label>Standard No.: </label>10.1016/j.jpba.2008.05.011  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aryl Hydrocarbon Hydroxylases--analysis<br/>Biological Assay<br/>Chromatography, Liquid--methods<br/>Cytochrome P-450 CYP1A2--analysis<br/>Cytochrome P-450 CYP2B6<br/>Cytochrome P-450 CYP2C19<br/>Cytochrome P-450 CYP2C9<br/>Cytochrome P-450 CYP2D6--analysis<br/>Cytochrome P-450 CYP3A--analysis<br/>Cytochrome P-450 Enzyme System--analysis<br/>Dextromethorphan--metabolism<br/>Diclofenac--metabolism<br/>Drug Interactions<br/>Humans<br/>Hydrogen-Ion Concentration<br/>Inhibitory Concentration 50<br/>Kinetics<br/>Microsomes, Liver--chemistry<br/>Midazolam--metabolism<br/>Miniaturization<br/>Oxidoreductases, N-Demethylating--metabolism<br/>Reference Standards<br/>Reproducibility of Results<br/>Sensitivity and Specificity<br/>Substrate Specificity--drug effects<br/>Tacrine--metabolism<br/>Tandem Mass Spectrometry--methods<br/>Time Factors