TY  - GEN
AU  - Cox,Christopher D
AU  - Coleman,Paul J
AU  - Breslin,Michael J
AU  - Whitman,David B
AU  - Garbaccio,Robert M
AU  - Fraley,Mark E
AU  - Buser,Carolyn A
AU  - Walsh,Eileen S
AU  - Hamilton,Kelly
AU  - Schaber,Michael D
AU  - Lobell,Robert B
AU  - Tao,Weikang
AU  - Davide,Joseph P
AU  - Diehl,Ronald E
AU  - Abrams,Marc T
AU  - South,Vicki J
AU  - Huber,Hans E
AU  - Torrent,Maricel
AU  - Prueksaritanont,Thomayant
AU  - Li,Chunze
AU  - Slaughter,Donald E
AU  - Mahan,Elizabeth
AU  - Fernandez-Metzler,Carmen
AU  - Yan,Youwei
AU  - Kuo,Lawrence C
AU  - Kohl,Nancy E
AU  - Hartman,George D
TI  - Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer
SN  - 1520-4804
PY  - 2008///0829
KW  - ATP Binding Cassette Transporter, Subfamily B, Member 1
KW  - metabolism
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Enzyme Inhibitors
KW  - Humans
KW  - Kinesins
KW  - antagonists & inhibitors
KW  - Neoplasms
KW  - drug therapy
KW  - Piperidines
KW  - Pyrroles
KW  - Taxoids
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm800386y
ER  -