Cox, Christopher D <br/><br/>
Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.  [electronic resource] 

 -  Journal of medicinal chemistry  Jul 2008 
 - 4239-52 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm800386y  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism<br/>Antineoplastic Agents--pharmacology<br/>Enzyme Inhibitors--pharmacology<br/>Humans<br/>Kinesins--antagonists & inhibitors<br/>Neoplasms--drug therapy<br/>Piperidines--pharmacology<br/>Pyrroles--pharmacology<br/>Taxoids--pharmacology