TY - GEN AU - Verbeek,Dineke S AU - Goedhart,Joachim AU - Bruinsma,Laurie AU - Sinke,Richard J AU - Reits,Eric A TI - PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling SN - 0021-9533 PY - 2008///1007 KW - Amino Acid Sequence KW - Cell Membrane KW - drug effects KW - Cell Nucleus KW - Cell Survival KW - Enzyme Activation KW - HeLa Cells KW - Humans KW - Kinetics KW - MAP Kinase Signaling System KW - Mitogen-Activated Protein Kinase 1 KW - metabolism KW - Molecular Sequence Data KW - Mutation KW - genetics KW - Protein Kinase C KW - chemistry KW - Protein Structure, Tertiary KW - Protein Transport KW - Spinocerebellar Ataxias KW - enzymology KW - Subcellular Fractions KW - Tetradecanoylphorbol Acetate KW - pharmacology N1 - Publication Type: Journal Article UR - https://doi.org/10.1242/jcs.027698 ER -