Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression. [electronic resource]
- PLoS genetics Jun 2008
- e1000092 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1553-7404
10.1371/journal.pgen.1000092 doi
Adenomatous Polyposis Coli Protein--genetics Adenosine Triphosphatases--genetics Alternative Splicing Animals Base Sequence Carrier Proteins--genetics Cell Line Cell Movement Cell Proliferation Co-Repressor Proteins Colorectal Neoplasms--genetics Core Binding Factor Alpha 3 Subunit--genetics DNA Mismatch Repair DNA Repair Enzymes--genetics DNA-Binding Proteins--genetics Disease Progression Female Gene Amplification Gene Dosage Humans Male Mice Mice, Inbred Strains Mice, Nude Mice, Transgenic Mismatch Repair Endonuclease PMS2 MutL Proteins Mutation Neoplasm Transplantation Protein Isoforms--genetics Repressor Proteins--genetics Transcription Factors--genetics Transcriptional Activation Transplantation, Heterologous