Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase-primase inhibitors, variously affect virus growth rate and pathogenicity. [electronic resource]
- Antiviral research Oct 2008
- 81-5 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0166-3542
10.1016/j.antiviral.2008.04.005 doi
Animals Antiviral Agents--pharmacology Chlorocebus aethiops DNA Helicases--antagonists & inhibitors DNA Primase--antagonists & inhibitors Drug Resistance, Viral--genetics Enzyme Inhibitors--pharmacology Herpes Simplex--pathology Herpesvirus 1, Human--drug effects Humans Mice Mice, Inbred BALB C Mutation Pyridines--pharmacology Sulfonamides Thiazoles--pharmacology Vero Cells Viral Proteins--antagonists & inhibitors Virulence