Overcoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines. [electronic resource]
- Molecular pharmacology Sep 2008
- 724-35 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1521-0111
10.1124/mol.108.047787 doi
Antineoplastic Agents--pharmacology Camptothecin--analogs & derivatives Cell Line, Tumor Cell Proliferation--drug effects Cell Survival--drug effects Checkpoint Kinase 1 DNA, Neoplasm--biosynthesis Deoxycytidine--analogs & derivatives Down-Regulation--drug effects Drug Resistance, Neoplasm--drug effects Drug Screening Assays, Antitumor Drug Synergism Humans Irinotecan Phosphorylation--drug effects Protein Kinases--metabolism Protein Processing, Post-Translational--drug effects RNA, Small Interfering--metabolism S Phase--drug effects Tumor Stem Cell Assay Gemcitabine